Calpain activates caspase-8 in neuron-like differentiated PC12 cells via the amyloid-β-peptide and CD95 pathways

Amyloid β peptide toxicity in differenti

Amyloid β peptide toxicity in differentiated PC12 cells: Calpain-calpastatin, caspase, and membrane damage

✍ Tali Vaisid; Nechama S. Kosower; Esther Elkind; Sivia Barnoy 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 686 KB

## Abstract Amyloid β peptide (Aβ) is implicated in the pathogenesis of Alzheimer's disease (AD). The peptide is toxic to neurons, possibly by causing initial synaptic dysfunction and neuronal membrane dystrophy, promoted by increased cellular Ca^2+^. Calpain (Ca^2+^‐dependent protease) and caspase