Inhibition of connexin43 gap junctional
✍
Randall J. Ruch; James E. Trosko; Burra V. Madhukar
📂
Article
📅
2001
🏛
John Wiley and Sons
🌐
English
⚖ 243 KB
## Abstract The phorbol ester, 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA), is a potent inhibitor of gap junctional intercellular communication (GJIC). This inhibition requires activation of protein kinase C (PKC), but the events downstream of this kinase are not known. Since PKC can activate ex