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Calibration of [123I]iodine-labeled tissue standards for autoradiographic studies

✍ Scribed by Eric W. Johnson; Elzbieta Sybirska; Mohammed Al-Tikriti; Robert B. Innis

Publisher
Elsevier Science
Year
1991
Weight
293 KB
Volume
42
Category
Article
ISSN
0883-2889

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✦ Synopsis

Autoradiographic images can be analyzed with computer-assisted microdensitometry relative to radioactive reference standards to provide quantitative measurements of regional radioactivity concentrations. [123I]Iodine containing sections of brain paste have been calibrated relative to plastic-embedded tritium(3H) and 125Iodine standards. For exposure times of 8, 12 and 24 h, plastic-embedded standards covered a range concentrations of [123I]iodine from 1000 to 100,000 dpm/mg wet weight. Iodine-123 radioactivity was linear with section thickness from 5 to 30 microns. These studies confirmed the feasibility of using commercially available longer-lived reference standards to provide [123I]iodine equivalent values in absolute units of dpm (or microCi) per mg tissue.

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