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Calibration for Nonlinear Mixed Effects Models: An Application to the Withdrawal Time Prediction

✍ Scribed by Didier Concordet; Olivier G. Nunez

Book ID
110724809
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
644 KB
Volume
56
Category
Article
ISSN
0006-341X

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A population pharmacokinetic (PK) analysis was performed on plasma concentrations of GW468816 observed in dogs after 10, 25, and 50 mg/kg/day repeated intravenous administration. A two-compartment model was fitted to the concentration-time data using the NONMEM program. Dose and time dependency of P