Calculations and Application of Mean Residence Times for Drugs Which Demonstrate One-Compartment Distribution and Michaelis-Menten Elimination
β Scribed by Jack A. Cook; Peter R. Gwilt
- Book ID
- 114421156
- Publisher
- Springer US
- Year
- 1988
- Tongue
- English
- Weight
- 152 KB
- Volume
- 05
- Category
- Article
- ISSN
- 0724-8741
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π SIMILAR VOLUMES
The equation for the calculation of mean residence time of drug in plasma, t(p), is obtained. It is shown that the previously suggested calculation of t(p) considerably overestimates the true value in most cases. It is suggested that due to the possible initial (before establishing the uniform drug
Based on disposition decomposition analysis (DDA), equations for the mean residence times (MRT) in the body are derived for a drug and its interconversion metabolite that undergo linear tissue distribution and linear or non-linear elimination from the central compartment after non-instantaneous admi