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Calculation of risk factors and likelihoods for familial diseases

โœ Scribed by C. Cannings; M.H. Skolnick; K. de Nevers; R. Sridharan

Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
731 KB
Volume
9
Category
Article
ISSN
0010-4809

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โœฆ Synopsis

This paper presents a method for solving two related problems in pedigree analysis. The first application involves fitting familial modes of transmission of a trait to pedigree data and includes chromosome linkage studies as a special case. The second application involves calculating the probability that a person will be affected with a disease given a model. Genetic, environmental, and combined models can be considered. Pedigrees of any complexity, including consanguinity, can be handled. The risks and likelihoods are calculated as coefficients of polynomials in the gene-frequencies rather than numerically.

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