Three multifunctional protein kinases, cyclic AMPdependent protein kinase, protein kinase C, and calmodulin-dependent protein kinase 11, are involved in signal transduction in response to their respective second messengers, cyclic AMP, diacylglycerol, and Ca2+. This review will summarize the key fin
Calcium/calmodulin-dependent protein kinase II: role in learning and memory
β Scribed by Thomas R. Soderling
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 930 KB
- Volume
- 127-128
- Category
- Article
- ISSN
- 0300-8177
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## Abstract Hippocampal Ξ±βcalcium/calmodulinβdependent protein kinase II (Ξ±CaMKII) has been implicated in neuronal plasticity and spatial learning. In the present experiment, an adenoβassociated virus (AAV) vector was designed to express Ξ±CaMKII driven by the U6 promotor. Microinfusion of this vect
Although Ca 2/ /calmodulin-depen-mRNA increase. We were unable to find CaM kinase dent (CaM) protein kinase II isoforms are present in IIa immunoreactivity before or after axotomy in scithe nervous system in high amounts, many aspects of atic motor neuron cell bodies, suggesting that CaM in vivo exp