Calcium antagonists do not inhibit vascular smooth muscle cell chemotaxis caused by platelet-derived growth factor
β Scribed by Michitaka Naito; Toshio Hayashi; Chiaki Funaki; Masafumi Kuzuya; Kanichi Asai; Fumio Kuzuya
- Book ID
- 118896070
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 195 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0021-9150
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Structural changes within the blood vessel wall such as hyperplasia and hypertrophy of vascular smooth muscle cells are important factors in the pathogenesis of hypertension. Humoral growth factors such as angiotensin II (AII) and platelet-derived growth factor BB (PDGF-BB) may participate in the re
Platelet-derived growth factor (PDGF) and angiotensin II (All) are thought to medi'ite their biological effects in vascular smooth muscle cells (VSMCs) by causing alterations in cytosolic free calcium (ICaL-],). In this study we examine the pathways b y which PDGF and All 'ilter l C a L f \ , in VSM