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Calcineurin inhibitors down-regulate iNOS expression by destabilising mRNA

✍ Scribed by Mari Hämäläinen; Riku Korhonen; Eeva Moilanen

Book ID
116576408
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
863 KB
Volume
9
Category
Article
ISSN
1567-5769

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## Abstract The mechanisms involved in the anti‐angiogenic actions of the proteasome inhibitors are poorly understood. Here, we report that the gene expression of the VEGF receptor Flt‐1 (vascular endothelial growth factor receptor 1) was down‐regulated by the reversible proteasome inhibitor MG262