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Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin

✍ Scribed by Samuel Koprak; Stephen Matheravidathu; Martin Springer; Sandra Gould; Francis J. Dumont

Book ID: 114008285
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 445 KB
Volume: 223
Category: Article
ISSN: 0008-8749
DOI: 10.1016/s0008-8749(03)00130-8

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## Abstract ## BACKGROUND Previous reports indicate that Genistein, a naturally occurring isoflavonoid, exhibits strong antiangiogenic activity. The underlying mechanism of inhibition, however, remains unclear. Among the biologic effects of Genistein are the inhibition of tyrosine kinases and the