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CAG-repeat expansion in androgen receptor in Kennedy's disease is not a loss of function mutation

✍ Scribed by Felizia Neuschmid-Kaspar; Andreas Gast; Heike Peterziel; Jean Schneikert; Armin Muigg; Gerhard Ransmayr; Helmut Klocker; Georg Bartsch; Andrew C.B. Cato


Book ID
116122744
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
865 KB
Volume
117
Category
Article
ISSN
0303-7207

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Uterine endometrial carcinoma is common among women. Several reports indicated that this cancer is influenced by androgens mediated through their receptors. The human androgen receptor gene contains a polymorphic CAG repeat in the coding region of exon 1. Other studies suggested a possible associati