## Abstract The objective of this study was to further explore the effect of CAG repeat length on the rate of clinical progression in patients with Huntington's disease. The dataset included records for 569 subjects followed prospectively at the Baltimore Huntington's Disease Center. Participants w
CAG mutation effect on rate of progression in Huntington's disease
โ Scribed by F. Squitieri; M. Cannella; M. Simonelli
- Publisher
- Springer Milan
- Year
- 2002
- Tongue
- English
- Weight
- 53 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1590-1874
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## Abstract The objective of this study was to examine the relationship between CAG repeat length (CAGn) and clinical progression in patients with Huntington's disease (HD). There are conflicting reports about the relationship between CAGn and clinical progression of HD. We conducted an analysis of
The Huntington's disease gene contains an expanded unstable (CAG), repeat, and the repeat lengths have been shown to correlate with the age of onset. Using detailed clinical scales, we evaluated the rate of progression of Huntington's disease and its relationship to the number of triplet repeats. We