Caffeine use and plasma concentrations in psychiatric outpatients
β Scribed by R. Gregory Lande; Lawrence A. Labbate
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 52 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1091-4269
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## Abstract The objective was to develop a population pharmacokineticβpharmacodynamic model of caffeine's psychomotor effects in healthy, nonβhabitual users of caffeine. Twenty Chinese males each received a single dose of 250βmg of caffeine orally. Plasma concentrations of caffeine were determined
Objectives[ Since plasma protein binding of tricyclic antidepressants may be relevant to treatment e}ects and can be in~uenced by age!associated factors\ we examined both plasma ultra\_ltrate and total concentrations of nor! triptyline "NT# in patients and compared these to age [ We hypothesized neg