Cadmium-induced forelimb ectrodactyly: A proposed mechanism of teratogenesis
โ Scribed by Feuston, Maureen H. ;Scott, William J.
- Book ID
- 112217545
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 1022 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-3709
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## Abstract ## BACKGROUND: Cadmium ion (Cd^2+^) is a ubiquitous environmental contaminant, and it is a potent teratogen in mice. An intraperitoneal dose of 4 mg/kg of CdCl~2~ at gestational day 9 causes forelimb ectrodactyly in the C57BL/6N mouse strain, but the SWV/Fnn strain is resistant. The ob
The p53 pathway plays an important role in the regulation of apoptosis, osteoblast differentiation, skeletal development, and teratogenic sensitivity. The administration of cadmium chloride (CdCl 2 ) on gestational day 9 in susceptible mouse strains causes postaxial forelimb ectrodactyly in a percen