Cadmium-induced postaxial forelimb ectrodactyly: association with altered sonic hedgehog signaling

Altered localization of gene expression

Altered localization of gene expression in both ectoderm and mesoderm is associated with a murine strain difference in retinoic acid–induced forelimb ectrodactyly

✍ Hirohito Shimizu; Grace S. Lee; Sudheer R. Beedanagari; Michael D. Collins 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 863 KB

## Abstract ## BACKGROUND: Defects in digit number or fusion as a teratogenic response are well documented in humans and intensively studied in various mouse models. Maternal exposure to excess levels of all‐__trans__‐retinoic acid (RA) at gestational day 9.5 induces postaxial ectrodactyly (digit