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Ca2+ channel antagonists inhibit the intestinal absorption of digoxin in the guinea-pig

✍ Scribed by Metka V. Budihna; Primǒz Strojan

Book ID
115888673
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
395 KB
Volume
230
Category
Article
ISSN
0014-2999

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✍ S. G. Schäfer; B. Fichtl; W. Doering 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 2 views

Following i.v. injection of digoxin (1Opg kg-') the ratio between digoxin concentrations in the lumen ofjejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearily with time. After 3 h, L/P was 8.7, indicating net secretion of digoxin against a concentration gradient. In qu