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Ca uptake and Ca releasing properties of the endoplasmic reticulum in rat peritoneal mast cells

✍ Scribed by Narihiko Yoshii; Mitsunobu Mio; Kenji Tasaka

Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
489 KB
Volume
16
Category
Article
ISSN
0162-3109

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We have examined the effect of the Ca2+ (Mg2+)-ATPase inhibitors thapsigargin (TG) and vanadate on ATP-dependent 45Ca2+ uptake into IP3-sensitive Ca2+ pools in isolated microsomes from rat pancreatic acinar cells. The inhibitory effect of TG was biphasic. About 40-50% of total Ca2+ uptake was inhibi