C12. Performances and applicability of electrochemical NO-sensor for in vivo detection of nitric oxide in tumor-bearing mice
✍ Scribed by S. Griveau; C. Dumézy; J. Seguin; G.G. Chabot; D. Scherman; F. Bedioui
- Book ID
- 116790411
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 58 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1089-8603
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## Abstract The ability of an inserted electrode to detect in vivo NO in tumor was achieved by using a chemically modified Pt/Ir electrode as NO‐sensor and nitroglycerin NTG as NO donor. Enzymatically induced release of NO from NTG was tracked in the tumor, upon intra peritoneal injection of NTG. T
Nitric oxide (NO) has been implicated both in regression and progression of tumors due to its production by both tumor cells and infiltrating leukocytes. Ionizing radiation causes the regression of tumors, and can augment the production of NO by macrophages in vitro. We examined the cellular and sys