C-nucleoside studies. Part 7. A new synthesis of showdomycin, 2-?-D-ribofuranosylmaleimide
โ Scribed by Buchanan, J. Grant; Edgar, Alan R.; Power, Michael J.; Shanks, Colin T.
- Book ID
- 120219619
- Publisher
- Royal Society of Chemistry
- Year
- 1979
- Weight
- 429 KB
- Volume
- 0
- Category
- Article
- ISSN
- 1472-7781
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l&kmboru et. 81: h&v8 18Olatul nebularIn fro8 Agrlow (Clltoojbo) llObUlari8 Bat8oh. bt8r, 180Zlo28t. 81. h8V8 detOotOd it 88 a mot8bollo produot of l 8tropto~oot8. Th. oompound 8hON8 a 8trOmg 8OtiVity 8giIk8t 10188 68mOU 180 and yOobacterl8. The 8truOture hs8 boa dotorrind. 88 9+-D-ribOfWXlo8,1pllri
Pyrazofurin A (VIII) and showdomycin (IV) are nucleosides havin? marked antiviral, antibacterial and antitumor activity2, and their syntheses have been re-ported3r4. We should like to describe the synthesis of their carbocyclic analogues IX and V. The readily available olefin ester I 5 was ozonoly