An improved route to coenzyme Q 10 (1) starting from commercially available coenzyme Q 1 is described. The key steps in this synthesis are the SeO 2 -mediated oxidation of the protected isoprenylhydroquinone 3 into the (E)-allyl alcohol 5 without the formation of undesired stereoisomer and the one-p
β¦ LIBER β¦
Nucleosides : Part LXXII. Synthetic studies on nucleoside antibiotics. 7. An improved synthesis of C-substance
β Scribed by K.A. Watanabe; Iris M. Wempen; J.J. Fox
- Book ID
- 108307960
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- English
- Weight
- 480 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0008-6215
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An efficient and stereoselective approach to the synthesis of coenzyme Q 10 is described (Scheme). The MeOCH 2 -protected p-hydroquinone 4 containing the C 5 (E)-allyl (tert-butyl)dimethylsilyl ether moiety was obtained via a halogen -lithium exchange of the MeOCH 2 -proctected 2-bromo-5,6dimethoxy-