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c-Fos dimerization with c-Jun represses c-Jun enhancement of androgen receptor transactivation

✍ Scribed by Karl Tillman; Jennifer L. Oberfield; Xi-Qiang Shen; Athanasios Bubulya; Lirim Shemshedini


Book ID
111638330
Publisher
Springer
Year
1998
Tongue
English
Weight
279 KB
Volume
9
Category
Article
ISSN
0969-711X

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Uncoiling c-Jun coiled coils: Inhibitory
✍ Shao Yao; Michelle Brickner; Elsie I. Pares-Matos; Jean Chmielewski πŸ“‚ Article πŸ“… 1998 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 218 KB

c-Jun is an oncoprotein that comprises a portion of the AP-1 transcription factor and belongs to the basic-leucine zipper (bZIP) DNA binding protein family. Using peptides derived from the leucine zipper region of Fos, we have developed agents that inhibit Jun's DNA binding in the low micromolar ran