C-erbB-2 expression in primary gastric carcinomas and their metastases
✍ Scribed by L David; R Seruca; JM Nesland; P Soares; F Sansonetty; R Holm; A-L Børresen; M Sobrinho-Simões
- Book ID
- 119105625
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 85 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0165-4608
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One hundred seventy-nine primary human gastric tumors not associated with early cancer or noncurative resection were examined immunohistochemically for the expression of c-erbB-2 protein. Positive staining, regarded as an indication of gene amplification, was evident in 22( 12%) of the tumors. Of va
## Abstract An immunohistochemical study of the c‐erbB‐2 protein was conducted on formalin‐fixed paraffin‐embedded tissue sections from 136 primary gastric carcinomas and 50 metastatic lymph node tumors obtained at gastrectomy. Expression of the protein was detected in 35 of 136 primary gastric car