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c-CBL is not required for leukemia induction by Bcr-Abl in mice

✍ Scribed by Dinulescu, Daniela M; Wood, Lisa J; Shen, Lei; Loriaux, Marc; Corless, Christopher L; Gross, Alec W; Ren, Ruibao; Deininger, Michael W N; Druker, Brian J

Book ID: 110067977
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 253 KB
Volume: 22
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1206892

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## Abstract Mutants and fusion products of the c‐abl gene were used to define some of the molecular requirements for rapid plasmacytoma (PC) and pre‐B‐lymphoma induction in pri5tane‐treated N‐__myc__ transgenic BALB/c mice. A‐MuLV induced PCs in 21 of 25 mice with a mean post‐pristane latency perio