C-Acylation of Electron-Rich Heterocyclic Compounds with Kirsanov Isocyanate. -Pyrroles (I), indoles (VI), indolizines (IX), and 2-methylfuran (XI) are smoothly and almost regioselectively C-acylated with isocyanatophosphoryl dichloride (Kirsanov isocyanate). The resulting heteroaryl-substituted di
C-acylation of electron-rich heterocyclic compounds with Kirsanov isocyanate
β Scribed by Andrei A. Tolmachev; Aleksandra A. Chaikovskaya; Radomir V. Smaliy; Tamara N. Kudrya; Aleksandr A. Yurchenko; Aleksandr M. Pinchuk
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 160 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1042-7163
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β¦ Synopsis
are vigorously C-acylated with isocyanatophosphoryl dichloride. The resulting heteroaryl-substituted isocyanatophosphoryl dichlorides provide a convenient access to a variety of products.
π SIMILAR VOLUMES
In acid-catalyzed reactions with 3-unsubstituted indoles 1,2-alkoxy-1,3-dioxolanes 2a-c behave as acyl equivalents. Depending on the substitution patterns of the reaction partners, the 1,3-dioxolanium ions 3a-c, generated in situ from the cyclic ortho esters by the action of sulfosalicylic acid, rea