C-8 Epimerizations of erythromycin B and 10,11-anhydroerythromycin B
✍ Scribed by Tadanier, Jack.; Martin, Jerry R.; Egan, Richard S.; Goldstein, Alma.; Hirner, Esther.; Fischer, Francis.
- Book ID
- 127238136
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 268 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0002-7863
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## Abstract Die gepufferte __m__‐Chlorperbenzoesäure‐Epoxydation von 8, 9‐Anhydroerythromycin‐B‐6, 9‐hemiacetal liefert nach der Reduktion der N‐Oxidgruppe stereoselektiv das (8__S__, 9__S__)‐8, 9‐Anhydro‐erythromycin‐B‐6, 9‐hemiacetal‐8, 9‐epoxid nebst einer geringen Menge des 8‐__epi__‐(8 __R__,
Abetract' To characterise the individual epimers of hepoxilin Bs, a new total synthesis procedure was developed consisting of subsequent condensations of enantromerically pure (2R,3S)-epoxy-5-undecynal with LiCmXXxCl and HCrC(C?iz)aC~Me, followed by Lindlar hydrogenation, and finally epimer separati