Bypass of Senescence After Disruption of p21CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts
β Scribed by Brown, J. P.
- Book ID
- 118207735
- Publisher
- American Association for the Advancement of Science
- Year
- 1997
- Tongue
- English
- Weight
- 595 KB
- Volume
- 277
- Category
- Article
- ISSN
- 0036-8075
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## Abstract Butyric acid is well recognized as a histone deacetylase (HDAC) inhibitor, and changes in histone acetylation are thought to alter gene expression. The mechanism by which sodium butyrate (NaB) induces p21^WAF1/CIP1^, a critical gene involved in the antiproliferative effect of NaB, was s
## Abstract It has been reported that genomic DNA methylation decreases gradually during cell culture and an organism's aging. However, less is known about the methylation changes of ageβrelated specific genes in aging. p21^Waf1/Cip1^ and p16^INK4a^ are cyclinβdependent kinase (Cdk) inhibitors that