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Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells

✍ Scribed by Sandra Maier; M. Cecilia Daroqui; Stefan Scherer; Stefan Roepcke; Anna Velcich; Shailesh M. Shenoy; Robert H. Singer; Leonard H. Augenlicht

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
249 KB
Volume
218
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

In stimulating maturation of colonic carcinoma cells, the short chain fatty acid butyrate, and 1α,25‐dihydroxyvitamin D~3~, were shown to attenuate transcription of the cyclin D1 gene, giving rise to truncated transcripts of this locus. Moreover, a sequence which is highly conserved in the human, mouse, rat, and dog genome was found in the 4 kb long intron 3 of the human cyclin D1 gene, and is capable of forming a hairpin structure similar to that of microRNA precursors. The expression of this sequence is also decreased by the attenuation. Thus, the transcriptional attenuation at the cyclin D1 locus not only down‐regulates the expression of this key gene in mucosal cell maturation and tumorigenesis, but may also abrogate the generation of a molecule that encompasses this conserved sequence in cyclin D1 intron 3. J. Cell. Physiol. 218: 638–642, 2009. © 2008 Wiley‐Liss, Inc.

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