Butirosins A and B, aminoglycoside antibiotics. III. Structures
β Scribed by Peter W.K. Woo; Henry W. Dion; Quentin R. Bartz
- Publisher
- Elsevier Science
- Year
- 1971
- Tongue
- French
- Weight
- 219 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Previous letters' have established the molecular formula of butirosins A (Ia) and B (Ib) as C21H41Ns01.s and have shown that three of the structural units, (S)-(-)-4-amino-Z-hydroxybutyric acid (II), neosamine C (2,6-diamino-2,6-dideoxy-D-glucose) (III), and a pentose (Dxylose (IVa) in Ia, D-ribose (IVb) in Ib), are individually attached, as amide and O-glyco-
π SIMILAR VOLUMES
The complete proton assignments of the aminoglycoside antibiotics, butirosin A, kanamycin A and kanamycin B, at pH 6.5 have been made through the use of various homonuclear and heteronuclear 2D NMR methods. Butirosin A NOESY experiments suggest a stacking arrangement between the xylose and 2,6-diami
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This accounts for 22 carbons and 23 protons. The three missing protons belong to 3 hydroxyl groups, which was confirmed by acetylation of 1 to form a triacetate [3, m/z 528 (M+)].