✦ LIBER ✦

The complete 1H NMR assignments of aminoglycoside antibiotics and conformational studies of butirosin A through the use of 2D NMR spectroscopy

✍ Scribed by James R. Cox; Engin H. Serpersu

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 409 KB
Volume: 271
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(95)00048-x

No coin nor oath required. For personal study only.

✦ Synopsis

The complete proton assignments of the aminoglycoside antibiotics, butirosin A, kanamycin A and kanamycin B, at pH 6.5 have been made through the use of various homonuclear and heteronuclear 2D NMR methods. Butirosin A NOESY experiments suggest a stacking arrangement between the xylose and 2,6-diamino-2,6-dideoxyglucose rings, while the 2-deoxystreptamine ring and its substituent, the (S)-4-amino-2-hydroxybutyryl group, extend away from the stacked rings. Informative long-range NOEs were observed for butirosin A but not with kanamycin A or kanamycin B. Many intra-ring NOEs were observed with all three aminoglycosides that confirm the proton assignments made in this study.

📜 SIMILAR VOLUMES

Complete 1H and 13C NMR spectral assignm

Complete 1H and 13C NMR spectral assignment of venturicidin A by 2D NMR spectroscopy

✍ Adolf Gogoll; David Tanner 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 664 KB

After correlation of the majority of signals by COSY and one-bond heteronuclear correlation, the complete assignment of the 'H and I3C NMR spectra of the macrolide antibiotic venturicidin A required the application of long-range CH coupling information. This was accessible by the COLOC-S and selecti

Complete assignment of the 1H and 13C NM

Complete assignment of the 1H and 13C NMR spectra and solution conformation of the antitumour antibiotic, Aclacinomycin A

✍ John A. Parkinson; Ian H. Sadler; Michael B. Pickup; Alethea B. Tabor 📂 Article 📅 1995 🏛 Elsevier Science 🌐 French ⚖ 411 KB

Complete 1H and 13C NMR Assignments of t

Complete 1H and 13C NMR Assignments of the Oligosaccharide Antibiotic Sch 27899

✍ Tze-Ming Chan; Rebecca M. Osterman; James B. Morton; Ashit K. Ganguly 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB 👁 1 views

The complete assignments of 1H and 13C data for Sch 27899 are described. The compound is an oligosaccharide antibiotic belonging to the class everninomicin. It has a molecular mass of 1629. The assignments are based on 2D HMQC, HMQC-TOCSY and HMBC experiments.

2D NMR Analysis of the polylactone deriv

2D NMR Analysis of the polylactone derivative of colominic acid. Complete 1H and 13C NMR chemical shift assignments

✍ Terrence M. Flaherty; Jacquelyn Gervay 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 182 KB

Colominic acid (1) is homologous to the weakly immunogenic group B capsular polysaccharide produced by Neisserria meningitidis that causes meningitis in humans [1].

Complete assignments of the 1H and 13C N

Complete assignments of the 1H and 13C NMR spectra of the macrolide antibiotic flavofungin; intramolecular hydrogen bonding and conformation

✍ László Szilágyi; Péter Sándor 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 773 KB

## Abstract ^1^H and ^13^C NMR spectra of the 32‐membered pentaene macrolide flavofungin‐I (identical with mycoticin A) in DMSO‐__d__~6~ solution were fully assigned employing a combination of various 1D and 2D homo‐ and hetero‐nuclear experiments. Secondary deuterium isotope shifts measured in the

Complete 1H and 13C NMR spectral assignm

Complete 1H and 13C NMR spectral assignment of some polynitropolycyclic cage molecules by 2D NMR spectroscopy

✍ T. Axenrod; B. Liang; P. R. Dave 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 649 KB