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Buthionine sulfoximine inhibition of cystine uptake and glutathione biosynthesis in human lung carcinoma cells

Book ID
123395824
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
100 KB
Volume
1
Category
Article
ISSN
0169-5002

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## Abstract Glutathione (GSH) has often been implicated in the mechanism of resistance to platinum anti‐cancer drugs. It has been suggested that GSH may reduce the cytotoxicity of these drugs by forming inactive conjugates and by enhancing the repair of DNA‐platinum crosslinks. In the present study