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Butein suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture

✍ Scribed by Sun Wook Woo; Sung Hee Lee; Hee-Chul Kang; Eun-Jeon Park; Yu-Zhe Zhao; Youn-Chul Kim; Dong Hwan Sohn


Book ID
111769220
Publisher
Pharmaceutical Press
Year
2003
Tongue
English
Weight
224 KB
Volume
55
Category
Article
ISSN
2042-7158

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Hepatic stellate cells are the major cellular sources of extracellular matrix in chronic liver diseases leading to fibrosis. We explored the antifibrogenic effect of two histone deacetylase inhibitors, sodium butyrate and trichostatin A (TSA), on this cell type in vitro. Primary hepatic stellate cel