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Burst production of superoxide anion in human endothelial cells by lysophosphatidylcholine

✍ Scribed by Kiyotaka Kugiyama; Seigo Sugiyama; Nobuhiko Ogata; Hideki Oka; Hideki Doi; Yasutaka Ota; Hirofumi Yasue

Book ID
119438295
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
85 KB
Volume
143
Category
Article
ISSN
0021-9150

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Bovine brain endothelial cells (EC) that were isolated and propagated in pure culture had increased (> 20-fold) levels of xanthine oxidase and xanthine dehydrogenase activity compared to whole brain homogenate. Brain EC also released superoxide anion (0;) into the extracellular medium. Treatment of