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Bunolol metabolism by dogs: Identification of basic metabolites and their conjugates

✍ Scribed by Franz-Josef Leinweber; R. Clive Greenough; Frederick J. Di Carlo

Book ID
102914369
Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
677 KB
Volume
66
Category
Article
ISSN
0022-3549

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✦ Synopsis

Female beagles dosed once with encapsulated 14C-bunolol (10 mg/kg) excreted 61% of the isotope in urine in 24 hr. The pooled urine contained a minimum of 18 labeled compounds. Two previously unknown metabolites were purified and were identified by UV and mass spectral data; they were hydroxybunolol (10.1% of urinary radioactivity) and hydroxydihydrobunolol (9.8%). The urine also contained bunolol (0.7% of urinary carbon-14), dihydrobunolol (0.5%), conjugated dihydrobunolol (2.8%), beta-(5-oxytetralonyl)lactic acid (16.3%), and (5-oxytetralonyl) acetic acid (7.1%).

πŸ“œ SIMILAR VOLUMES

Bunolol metabolism by dogs: Isolation an
Bunolol metabolism by dogs: Isolation and identification of two acidic metabolites
✍ Franz-Josef Leinweber; R. Clive Greenough; Charles F. Schwender; Lloyd J. Haynes πŸ“‚ Article πŸ“… 1971 πŸ› John Wiley and Sons 🌐 English βš– 415 KB

The urine collected from three dogs for 24 hr. after oral administration of but~olol-'~C contained 61.2% of the administered radioactivity. An acidic metabolite, representing 16% of the urinary IrC, was purified by ether extraction and preparative TLC. The methyl ester of the metabolite was prepared