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Brønsted Acid Mediated Heterogeneous Addition Reaction of 1,3-Dicarbonyl Compounds to Alkenes and Alcohols

✍ Scribed by Ken Motokura; Noriaki Fujita; Kohsuke Mori; Tomoo Mizugaki; Kohki Ebitani; Kiyotomi Kaneda

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
120 KB
Volume
45
Category
Article
ISSN
0044-8249

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✦ Synopsis

From the standpoint of atom efficiency, [1] nucleophilic additions to alkenes or alcohols instead of alkyl halides are attractive salt-free methods (Scheme 1). Simple alkenes are readily accessible and abundant carbon-atom sources, but intermolecular additions of 1,3-dicarbonyl compounds to simple alkenes remain problematic. In traditional acid-or base-catalyzed Michael reactions of 1,3-dicarbonyl com-

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✍ Hui-Lan Yue; Wei Wei; Ming-Ming Li; Yong-Rong Yang; Jian-Xin Ji 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 1 views

## Abstract A novel and efficient trifluoromethanesulfonic acid‐catalyzed __sp__^3^‐__sp__^2^ CC bond formation reaction through the direct coupling of alcohols with alkenes has been realized under mild conditions. The present protocol provides an attractive approach to a diverse range of polysubs