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Brønsted Acid-Catalyzed Nucleophilic Substitution of Alcohols

✍ Scribed by Roberto Sanz; Alberto Martínez; Delia Miguel; Julia M. Álvarez-Gutiérrez; Félix Rodríguez

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
160 KB
Volume
348
Category
Article
ISSN
1615-4150

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directly by flash column chromatography on silica gel (hexanes/ EtOAc = 10:1 to 5:1) to afford product 2 a (30.6 mg, 94 % yield, 96 % ee). Enantiomeric excess was determined by HPLC analysis using a chiral column.