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Bryostatins revisited: a new bryostatin 3 and the use of NMR to determine stereochemistry in the C-20-C-23 area

โœ Scribed by Chmurny, Gwendolyn N.; Koleck, Mary P.; Hilton, Bruce D.


Book ID
126430527
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
599 KB
Volume
57
Category
Article
ISSN
0022-3263

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The synthesis and biological assay of a new series of designed bryostatin analogues modiยฎed at the C20 position are described. These compounds are found to bind to protein kinase C with anities of up to 1.5 nM, demonstrating that variations at C20 can indeed be used to tune anity and potentially fun