An aqueous fraction (10-300 mg/mL) of the ethanol extract of the leaves of Cissampelos sympodialis Eichl inhibited N-formyl-Met-Leu-Phe (fMLP)-induced release of lysozyme and myeloperoxidase from human neutrophils. Inhibition by the fraction, as well as by dibutyryl-cAMP and prostaglandin E 2 , was
Bronchodilator activity of an aqueous fraction of an ethanol extract of the leaves of Cissampelos sympodialis Eichl. (Menispermaceae) in the guinea pig
✍ Scribed by G. Thomas; C.C. Araújo; J.C. Duarte; D.P. De Souza
- Book ID
- 114307214
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 887 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0944-7113
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An aqueous fraction of the ethanol extract of the leaves (AFL) of Cissampelos sympodialis Eichl. (Menispermaceae) was shown to relax the spontaneous tone of guinea-pig tracheal smooth muscle rings with an IC 50 of 20.5 g/mL. The AFL inhibited cyclic nucleotide phosphodiesterase activity in isolated
The potential of the potassium channel activator cromakalim and its active enantiomer BRL 38227 as inhaled bronchodilators has been evaluated in the guinea-pig, in comparison with nifedipine, salbutamol and aminophylline. Inhaled cromakalim and BRL 38227 prolonged the time before histamine-induced c