Bromodimethylsulfonium Bromide-Silver Triflate: A New Powerful Promoter System for the Activation of Thioglycosides

✍ Scribed by De-Cai Xiong; Li-He Zhang; Xin-Shan Ye

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 242 KB
• Volume: 350
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.200800190

✦ Synopsis

Abstract

Bromodimethylsulfonium bromide (BDMS) in combination with silver triflate provides a very efficient thiophilic promoter system, capable of activating both “disarmed” and “armed” thioglycosides for glycosidic bond formation. The usefulness of this new promoter is illustrated by a successful reactivity‐based one‐pot oligosaccharide assembly.