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Brominated 4-(Trifluoromethyl)pyrimidines: A Convenient Access to Versatile Intermediates

✍ Scribed by Levente Ondi; Olivier Lefebvre; Manfred Schlosser

Book ID
102175686
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
106 KB
Volume
2004
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

An expedient route to all three monobrominated and all three dibrominated isomers of 4‐(trifluoromethyl)pyrimidine, and to several other halogenated pyrimidines, is described. Key steps are the electrophilic introduction of the halogen in the 5‐position of 2‐ or 4‐pyrimidinones, the bromodeoxygenation of pyrimidinones or thiopyrimidinones using phosphorus tribromide, and the partial debromination of dibromo‐4‐(trifluoromethyl)pyrimidines. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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