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BroadBRCA1andBRCA2mutational spectrum and high incidence of recurrent and novel mutations in the eastern Spain population

✍ Scribed by Eva Esteban Cardeñosa; Pascual Bolufer Gilabert; Inmaculada de Juan Jimenez; Sarai Palanca Suela; Eva Barragán González; Isabel Chirivella González; Ángel Segura Huerta; Carmen Guillén Ponce; Eduardo Martínez de Dueñas

Publisher: Springer US
Year: 2009
Tongue: English
Weight: 177 KB
Volume: 121
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-009-0680-y

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## Abstract The prevalence of __BRCA1/2__ germ‐line mutations was assessed in a prospective population‐based series of early‐onset breast cancer (BC) patients in France, and the usefulness of a clinical assessment of hereditary BC risk, based on multiple criteria including pedigree structure, was e