Previous mutational analysis for BRCA gene mutations in sporadic ovarian cancer occurring in Chinese patients in Hong Kong identified six germline BRCA1 mutations and one germline BRCA2 mutation, six of which were novel (Khoo et al., 2000). Knowledge of BRCA gene mutations in the Chinese population
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Hereditary breast cancer in Middle Eastern and North African (MENA) populations: identification of novel, recurrent and founder BRCA1 mutations in the Tunisian population
โ Scribed by Wijden Mahfoudh; Noureddine Bouaouina; Slim Ben Ahmed; Sallouha Gabbouj; Jingxuan Shan; Rebecca Mathew; Nancy Uhrhammer; Yves-Jean Bignon; Wafa Troudi; Amel Ben Ammar Elgaaied; Elham Hassen; Lotfi Chouchane
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 260 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0301-4851
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Germline mutations within the adenomatous polyposis coli (APC) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations within thi