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Broad-Spectrum Antiviral Activity of Nucleic Acid-Based Antiviral Agents Against Avian and Seasonal Influenza Viruses

โœ Scribed by J.P. Wong; M.E. Christopher; L.Q. Sun; M. Wang; A.M. Salazar; S. Viswanathan


Book ID
118450262
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
52 KB
Volume
12
Category
Article
ISSN
1201-9712

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## Abstract The therapeutic activity of arbidol was investigated against representatives of seven different virus families. Its 50% median effective concentration (EC~50~) was 0.22โ€“11.8โ€‰ยตg/ml (0.41โ€“22โ€‰nM). Therapeutic indices of 91 were obtained for type 1 poliovirus and 1.9โ€“8.5 for influenza A and