Brief report novel mechanism for valproate-induced teratogenicity
โ Scribed by Fathe, Kristin; Palacios, Ana; Finnell, Richard H.
- Book ID
- 125805706
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 225 KB
- Volume
- 100
- Category
- Article
- ISSN
- 1542-0752
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Valproic acid (VPA, 2-propylpentanoic acid) is an established drug in the long-term therapy of epilepsy. During the past years, it has become evident that VPA is also associated with anti-cancer activity. VPA not only suppresses tumor growth and metastasis, but also induces tumor differentiation in
Antiepileptic drugs (AEDs), such as phenytoin (PHT), carbamazepine (CBZ), trimethadione (TMD), and phenobarbital (PB), have all been associated with a similar pattern of malformations, as well as growth retardation and developmental delay. Valproic acid (VPA) has been associated with a different pat