Brief Report: Large-scale analysis of tumor necrosis factor α levels in systemic lupus erythematosus
✍ Scribed by Corinna E. Weckerle; Dorothy Mangale; Beverly S. Franek; Jennifer A. Kelly; Marissa Kumabe; Judith A. James; Kathy L. Moser; John B. Harley; Timothy B. Niewold
- Book ID
- 115550457
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 115 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0004-3591
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The polymorphic tumor necrosis factor a (TNFa) gene encodes a cytokine involved in inflammation, angiogenesis, and apoptosis. One polymorphic variant is associated with increased production of TNFa. This study examined the frequency of this polymorphic variant in African-American patients with syste
## Abstract ## Objective To investigate the safety of therapeutic tumor necrosis factor α (TNFα) blockade in patients with systemic lupus erythematosus (SLE), in whom this proinflammatory cytokine is significantly increased and may be involved in the disease pathogenesis. ## Methods In an open‐l