𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A promoter polymorphism of tumor necrosis factor α associated with systemic lupus erythematosus in African-Americans

✍ Scribed by Kathleen E. Sullivan; Candra Wooten; Barbara J. Schmeckpeper; Daniel Goldman; Michelle A. Petri

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
556 KB
Volume
40
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

✦ Synopsis

The polymorphic tumor necrosis factor a (TNFa) gene encodes a cytokine involved in inflammation, angiogenesis, and apoptosis. One polymorphic variant is associated with increased production of TNFa. This study examined the frequency of this polymorphic variant in African-American patients with systemic lupus erythematosus (SLE) compared with controls.

Methods. We determined the gene frequency of the polymorphic variant of TNFa in an African-American SLE patient population and in a geographically matched African-American control population.

Results. The gene frequency of the TNFa -308A polymorphism was higher in the African-American SLE population than in the control population. This relationship was independent of major histocompatibility complex DR alleles.

Conclusion.

The TNFa -308A polymorphism is associated with an increased risk of SLE in African-Americans.

Tumor necrosis factor a (TNFa) is a proinflammatory cytokine that regulates the acute-phase response, vascular adhesion, bone marrow progenitor differentiation, and apoptosis (1,2). It has been implicated

📜 SIMILAR VOLUMES

Tumor necrosis factor-α promoter polymor
Tumor necrosis factor-α promoter polymorphism is associated with the risk of Parkinson's disease
✍ Yih-Ru Wu; I-Hsin Feng; Rong-Kuo Lyu; Kuo-Hsuan Chang; Yu-Yun Lin; Huiling Chan; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 73 KB 👁 1 views

## Abstract Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case‐control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor‐α (__TNF‐α__) promoter single n

Association of a tumor necrosis factor p
Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis
✍ J Grove; A K Daly; M F Bassendine; C P Day 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB

bility to ALD have thus far focused primarily on genes encod-SEE EDITORIAL ON PAGE 232 ing ethanol metabolizing enzymes. Results have been conflicting, but it would appear that the known polymorphisms of genes encoding the alcohol and aldehyde dehydro-Twin concordance studies suggest that genetic f

Safety and efficacy of tumor necrosis fa
Safety and efficacy of tumor necrosis factor α blockade in systemic lupus erythematosus: An open-label study
✍ Martin Aringer; Winfried B. Graninger; Günter Steiner; Josef S. Smolen 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 1 views

## Abstract ## Objective To investigate the safety of therapeutic tumor necrosis factor α (TNFα) blockade in patients with systemic lupus erythematosus (SLE), in whom this proinflammatory cytokine is significantly increased and may be involved in the disease pathogenesis. ## Methods In an open‐l