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Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1

✍ Scribed by Gupta, Anu; Inaba, Satoru; Wong, Oi Kwan; Fang, Guowei; Liu, Jingwen

Book ID: 110067965
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 278 KB
Volume: 22
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1206880

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Mutations in mitotic checkpoint genes have been detected in several human cancers, and these cancers exhibit chromosomal instability. Aneuploid stem cells seem to result from chromosomal instability and have been reported in many lung cancers. To determine whether alteration of mitotic checkpoint re