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The mitotic checkpoint gene BubR1 has two distinct functions in mitosis

✍ Scribed by Loleta Harris; James Davenport; Geoffrey Neale; Rakesh Goorha


Book ID
118506135
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
786 KB
Volume
308
Category
Article
ISSN
0014-4827

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## Abstract Aneuploidy and genetic instability are a hallmark of colorectal cancer and other solid tumors, and they are thought to enhance tumor progression. The gene __MAD2L____2__ (mitotic arrest deficient 2‐like 2) encodes the spindle checkpoint protein MAD2L2 (or MAD2B), a key component of a su