## Abstract MDR in human cancers is one of the major causes of failure of chemotherapy. A member of the superfamily of ABC transporters, BCRP, was demonstrated to confer an atypical MDR phenotype to tumor cells. To overcome the BCRPโmediated drug resistance, the fungal secondary metabolite TPSโA, a
Breast cancer resistance protein: Molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics
โ Scribed by Yoshikazu Sugimoto; Satomi Tsukahara; Etsuko Ishikawa; Junko Mitsuhashi
- Book ID
- 108583522
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 236 KB
- Volume
- 96
- Category
- Article
- ISSN
- 1347-9032
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## Abstract Breast cancer resistance protein (BCRP/ABCG2) of an ATPโbinding cassette halfโtransporter confers resistance against mitoxantrone and camptothecin derivatives of topotecan and irinotecan. Novobiocin, a coumermycin antibiotic, is known to enhance anticancer drug sensitivity of cancer cel
Heat shock proteins (Hsps) are induced in vitro by several cytotoxic drugs; in human breast cancer cells these proteins appear to be involved in anti-cancer drug resistance. The present report was designed to analyze whether chemotherapy affects in vivo the expression of Hsp27, Hsp70, Hsc70 and Hsp9