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Breakpoint cluster region rearrangements in chronic myelogenous leukemia with a masked Philadelphia chromosome

✍ Scribed by Junko H. Ohyashiki; Kazuma Ohyashiki; Alan J. Kinniburgh; Azra Raza; Harvey D. Preisler; Avery A. Sandberg


Book ID
119103526
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
438 KB
Volume
25
Category
Article
ISSN
0165-4608

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Background. Five to 10% of patients with chronic myelogenous leukemia (CML) do not have the Philadelphia chromosome (Ph), but one-third of them have rearrangements of the breakpoint cluster region (BCR-positive). Methods. The authors analyzed the characteristics, treatment response, and prognosis o

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We report on the first Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) characterized by a rearrangement within the 5' part of the bcr gene on chromosome 22, but outside the restricted breakpoint cluster region. In situ hybridization studies revealed a translocation of the c-