Germline mutations of BRCA2 were examined in 20 Japanese breast cancer families without BRCA1 mutations, including one demonstrating cancer development in a male. Three different mutations, resulting in truncation of the BRCA2 protein, were detected in 3 different families. They were 9474insA (exon
BRCA2 mutation in a family with hereditary prostate cancer
✍ Scribed by Henrik Grönberg; Anna-Karin Åhman; Monica Emanuelsson; Anders Bergh; Jan-Erik Damber; Åke Borg
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 71 KB
- Volume
- 30
- Category
- Article
- ISSN
- 1045-2257
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## BACKGROUND. Two genes responsible for hereditary breast cancer (BRCA1 and BRCA2) have been identified, and predisposing mutations identified. Several studies have provided evidence that germline mutations in BRCA1 and BRCA2 confer an increased risk of prostate cancer. Based on these findings, o
BACKGROUND. Families with a high incidence of hereditary breast cancer, and subsequently shown to have terminating mutations in BRCA1 or BRCA2, appear to have a higher incidence of prostate cancer among male relatives. We aimed to determine whether the common germline mutations of BRCA1 or BRCA2 in